Evolution of myeloid leukemia in children with Down syndrome

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Myeloid leukemia associated with Down syndrome.

A 2-year-old girl with Down syndrome (DS) presented to the emergency department after developing easy bruising and a petechial rash on her arms, legs, and face. Her laboratory results on admission were significant for anemia and thrombocytopenia: white blood cells, 10.1 3 10/L; hemoglobin, 6.6 g/dL; hematocrit, 19.4%; mean corpuscular volume, 102.6 fL; red cell distribution width, 15.7%; and pl...

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Acute leukemia in children with Down syndrome

Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA. Division of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit, MI, USA. Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA. Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA. E-mail: [email protected]. doi:10.33...

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Clinical characteristics and outcome of refractory/relapsed myeloid leukemia in children with Down syndrome.

Myeloid leukemia in Down syndrome (ML-DS) is associated with good response to chemotherapy and favorable prognosis. Because little research has been focused on refractory/relapsed (R/R) cases, we conducted a retrospective analysis for R/R ML-DS. Among ML-DS patients diagnosed between 2000 and 2010 in Japan, 26 relapsed (25 in the BM and 1 in the skin), and 3 refractory patients were enrolled. T...

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Balance Assessment in Children with Down Syndrome Who Practice Dance

Background. It is observed that dance delivers a valuable contribution to the development of bodily motor functions. Objectives. To evaluate the static and dynamic balance in children with Down syndrome - DS enrolled in a Dance Workshop for people with disabilities. Methods. Balance tests proposed by Oliveira (2009) were used on 14 children with DS aged between 8 and 12 (mean 9.36 ± 1.2 years...

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Speech Intelligibility in Persian Children with Down Syndrome

Objectives: One of the most effective methods to describe speech disorders is the measurement of speech intelligibility. The speech intelligibility indicates the extent of acoustic signals that correctly speaker produces and hearer receives. The purpose of this study was to investigate the speech intelligibility in the Persian children with Down syndrome, age range was 3 to 5 years, who had spo...

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ژورنال

عنوان ژورنال: International Journal of Hematology

سال: 2016

ISSN: 0925-5710,1865-3774

DOI: 10.1007/s12185-016-1959-5